Tencent scBert Single-Cell Pretraining Model
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About this skill
Problem
Single-cell pipelines often rely on a specific NEXTFLOW app on a hosted platform, but agent sessions can easily drift into out-of-scope commands, missing auth or project config, and name conflicts that break runs. This skill narrows the workflow to Tencent Health Omics Platform's scBert single-cell pretraining model for fine-grained annotation, novel subpopulation discovery, and Marker selection.
How It Works
- Command scoping: It builds commands through
scripts/omics_cli.py, with a lockedAppId,NEXTFLOWapp type, and public-app parameters. - Prechecks: It checks
whoamiandconfig show; trial users also receive quota checks based on remaining days and today's run budget. - Name protection: Before import, it enforces a same-name check using
--type NEXTFLOW, and asks for a new name on conflict instead of overwriting. - Run constraints: It requires selecting
nf_version, uses the defaultInputTemplate, and allows--inputoverrides; local file inputs must be uploaded to COS first.
Boundaries
- App-only scope: It cannot run other applications, project-owned apps, or substitute another
AppId. - Failure handling: Out-of-scope commands, auth failures, or missing platform configuration should be handled by the skill's guidance,
omics login, or the platform setup flow.
Use Cases
- Run scBert in a single-cell project to perform fine-grained cell annotation and inspect the output directory.
- Use scBert when undefined subpopulations need discovery and candidate Marker genes need selection.
- Upload locally generated reference sequences to COS first, then run scBert with that input.
- When a run fails, use the exit code to check auth, NF version, or parameter merge errors.
Best For
- A biomedical researcher analyzing single-cell transcriptomics who needs to run scBert on the Tencent Health Omics platform for cell annotation.
- A bioinformatics engineer maintaining Nextflow single-cell pipelines who wants to submit a fixed scBert public-app task.
- A research assistant who needs to run locally generated FASTA or reference files on the platform by uploading them to COS first.
- A trial-quota omics platform user who needs to check remaining days and today's run budget before submission.
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