Single-Drug Adverse-Effect Hub-First Network Pharmacology Planner

A Research Design Tool for Single-Drug Adverse Effects

When a study is built around one fixed drug and one toxicity phenotype, such as Escitalopram with long QT syndrome or Cisplatin with nephrotoxicity, the difficult part is not collecting targets. It is defining a defensible overlap space, using PPI topology to prioritize hubs, separating enrichment interpretation from docking plausibility, and avoiding a literature list that looks comprehensive but is not executable. This skill constrains input to drug + adverse-effect endpoint + research emphasis, and asks for a concrete study plan rather than a generic method review.

Workflow, Evidence Discipline, and Limits

It infers the study type, selects a hub-first pattern such as Canonical, Cardiotoxicity, Immune-Inflammatory, Organ-Toxicity, or Translational Validation, and always returns Lite, Standard, Advanced, and Publication+ configurations. It then recommends one primary path, checks dependency consistency, and maps steps such as fixed drug + fixed adverse-effect endpoint + overlap targets + hub prioritization + enrichment. The output includes the scientific question, configuration table, step-by-step workflow, figure plan, validation hierarchy, and a minimal executable version. Citations require stable identifiers such as DOI or PMID, and unverified papers must not be listed as formal references. The skill is not for patient-specific medication advice, dosing decisions, multi-drug exposure comparison, pure pharmacovigilance without a network backbone, or wet-lab-only toxicology without computational design.